Cheminformatics toolkit for fine-grained molecular control. SMILES/SDF parsing, descriptors (MW, LogP, TPSA), fingerprints, substructure search, 2D/3D generation, similarity, reactions. For standard workflows with simpler interface, use datamol (wrapper around RDKit). Use rdkit for advanced control, custom sanitization, specialized algorithms.

Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.

Use to manage pricing, packaging, and approval workflows for renewal negotiations.

Work with MongoDB (document database, BSON documents, aggregation pipelines, Atlas cloud) and PostgreSQL (relational database, SQL queries, psql CLI, pgAdmin). Use when designing database schemas, writing queries and aggregations, optimizing indexes for performance, performing database migrations, configuring replication and sharding, implementing backup and restore strategies, managing database users and permissions, analyzing query performance, or administering production databases.

Claude Code plugin enforcing operational guidelines, terse responses, sequential execution, and no destructive operations without confirmation.

NGS analysis toolkit. BAM to bigWig conversion, QC (correlation, PCA, fingerprints), heatmaps/profiles (TSS, peaks), for ChIP-seq, RNA-seq, ATAC-seq visualization.

Create beautiful, accessible user interfaces with shadcn/ui components (built on Radix UI + Tailwind), Tailwind CSS utility-first styling, and canvas-based visual designs. Use when building user interfaces, implementing design systems, creating responsive layouts, adding accessible components (dialogs, dropdowns, forms, tables), customizing themes and colors, implementing dark mode, generating visual designs and posters, or establishing consistent styling patterns across applications.

Collection of AWS development skills covering CDK infrastructure as code, cost optimization, and serverless/event-driven architectures with integrated MCP servers.

Complete API integration guide for Shopify including GraphQL Admin API, REST Admin API, Storefront API, Ajax API, OAuth authentication, rate limiting, and webhooks. Use when making API calls to Shopify, authenticating apps, fetching product/order/customer data programmatically, implementing cart operations, handling webhooks, or working with API version 2025-10. Requires fetch or axios for JavaScript implementations.

Quantum computing framework for building, simulating, optimizing, and executing quantum circuits. Use this skill when working with quantum algorithms, quantum circuit design, quantum simulation (noiseless or noisy), running on quantum hardware (Google, IonQ, AQT, Pasqal), circuit optimization and compilation, noise modeling and characterization, or quantum experiments and benchmarking (VQE, QAOA, QPE, randomized benchmarking).

专业的比特币钱包连接技能，支持btc-connect core、react、vue包在React、Vue、Next.js、Nuxt 3项目中的完整集成，包含UniSat和OKX钱包适配、网络切换功能、SSR环境配置、统一Hook API和v0.5.0最新特性

Generate typed TypeScript SDKs for AI agents to interact with MCP servers. Converts verbose JSON-RPC curl commands to clean function calls (docs.createDocument() vs curl). Auto-detects MCP tools from server modules, generates TypeScript types and client methods, creates runnable example scripts. Use when: building MCP-enabled applications, need typed programmatic access to MCP tools, want Claude Code to manage apps via scripts, eliminating manual JSON-RPC curl commands, validating MCP inputs/outputs, or creating reusable agent automation.

Access European Nucleotide Archive via API/FTP. Retrieve DNA/RNA sequences, raw reads (FASTQ), genome assemblies by accession, for genomics and bioinformatics pipelines. Supports multiple formats.

Manage BAP (Bitcoin Attestation Protocol) identity files using bap-cli. This skill should be used when users need to create, decrypt, list, or extract BAP identity backups, work with .bep encrypted files, or generate test fixtures for Playwright tests involving BAP identities.

Execute structured task plans with status tracking. Use when the user provides a plan file path in the format `plans/{current-date}-{task-name}-{version}.md` or explicitly asks you to execute a plan file.

Access NCBI GEO for gene expression/genomics data. Search/download microarray and RNA-seq datasets (GSE, GSM, GPL), retrieve SOFT/Matrix files, for transcriptomics and expression analysis.

Query NCBI Gene via E-utilities/Datasets API. Search by symbol/ID, retrieve gene info (RefSeqs, GO, locations, phenotypes), batch lookups, for gene annotation and functional analysis.

Process and generate multimedia content using Google Gemini API. Capabilities include analyze audio files (transcription with timestamps, summarization, speech understanding, music/sound analysis up to 9.5 hours), understand images (captioning, object detection, OCR, visual Q&A, segmentation), process videos (scene detection, Q&A, temporal analysis, YouTube URLs, up to 6 hours), extract from documents (PDF tables, forms, charts, diagrams, multi-page), generate images (text-to-image, editing, composition, refinement). Use when working with audio/video files, analyzing images or screenshots, processing PDF documents, extracting structured data from media, creating images from text prompts, or implementing multimodal AI features. Supports multiple models (Gemini 2.5/2.0) with context windows up to 2M tokens.

Keeps IdeaVim documentation in sync with code changes. Use this skill when you need to verify documentation accuracy after code changes, or when checking if documentation (in doc/, README.md, CONTRIBUTING.md) matches the current codebase. The skill can work bidirectionally - from docs to code verification, or from code changes to documentation updates.

Optimize provider selection, routing, and credit usage across 150+ enrichment sources for company/contact intelligence.