Work with MongoDB (document database, BSON documents, aggregation pipelines, Atlas cloud) and PostgreSQL (relational database, SQL queries, psql CLI, pgAdmin). Use when designing database schemas, writing queries and aggregations, optimizing indexes for performance, performing database migrations, configuring replication and sharding, implementing backup and restore strategies, managing database users and permissions, analyzing query performance, or administering production databases.

Use to manage pricing, packaging, and approval workflows for renewal negotiations.

Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.

Comprehensive healthcare AI toolkit for developing, testing, and deploying machine learning models with clinical data. This skill should be used when working with electronic health records (EHR), clinical prediction tasks (mortality, readmission, drug recommendation), medical coding systems (ICD, NDC, ATC), physiological signals (EEG, ECG), healthcare datasets (MIMIC-III/IV, eICU, OMOP), or implementing deep learning models for healthcare applications (RETAIN, SafeDrug, Transformer, GNN).

Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis.

Review code using Linus Torvalds' "good taste" philosophy. Eliminates defensive code, special cases, and deep nesting. Use when reviewing code quality, refactoring, or checking for code smells.

Comprehensive Python library for astronomy and astrophysics. This skill should be used when working with astronomical data including celestial coordinates, physical units, FITS files, cosmological calculations, time systems, tables, world coordinate systems (WCS), and astronomical data analysis. Use when tasks involve coordinate transformations, unit conversions, FITS file manipulation, cosmological distance calculations, time scale conversions, or astronomical data processing.

Use when users need to debug, modify, or extend the code-forge application's CLI commands, argument parsing, or CLI behavior. This includes adding new commands, fixing CLI bugs, updating command options, or troubleshooting CLI-related issues.

Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.

Pythonic wrapper around RDKit with simplified interface and sensible defaults. Preferred for standard drug discovery: SMILES parsing, standardization, descriptors, fingerprints, clustering, 3D conformers, parallel processing. Returns native rdkit.Chem.Mol objects. For advanced control or custom parameters, use rdkit directly.

Build Shopify applications, extensions, and themes using GraphQL/REST APIs, Shopify CLI, Polaris UI components, and Liquid templating. Capabilities include app development with OAuth authentication, checkout UI extensions for customizing checkout flow, admin UI extensions for dashboard integration, POS extensions for retail, theme development with Liquid, webhook management, billing API integration, product/order/customer management. Use when building Shopify apps, implementing checkout customizations, creating admin interfaces, developing themes, integrating payment processing, managing store data via APIs, or extending Shopify functionality.

Autonomous biomedical AI agent framework for executing complex research tasks across genomics, drug discovery, molecular biology, and clinical analysis. Use this skill when conducting multi-step biomedical research including CRISPR screening design, single-cell RNA-seq analysis, ADMET prediction, GWAS interpretation, rare disease diagnosis, or lab protocol optimization. Leverages LLM reasoning with code execution and integrated biomedical databases.

Interactive scientific and statistical data visualization library for Python. Use when creating charts, plots, or visualizations including scatter plots, line charts, bar charts, heatmaps, 3D plots, geographic maps, statistical distributions, financial charts, and dashboards. Supports both quick visualizations (Plotly Express) and fine-grained customization (graph objects). Outputs interactive HTML or static images (PNG, PDF, SVG).

Execute Gemini CLI for AI-powered code analysis and generation. Use when you need to leverage Google's Gemini models for complex reasoning tasks.

CLI/Python toolkit for rapid bioinformatics queries. Preferred for quick BLAST searches. Access to 20+ databases: gene info (Ensembl/UniProt), AlphaFold, ARCHS4, Enrichr, OpenTargets, COSMIC, genome downloads. For advanced BLAST/batch processing, use biopython. For multi-database integration, use bioservices.

Run SQL queries against the WordPress development database. Use when querying database tables, inspecting Simple History events, checking WordPress data, or debugging database issues.

Comprehensive toolkit for protein language models including ESM3 (generative multimodal protein design across sequence, structure, and function) and ESM C (efficient protein embeddings and representations). Use this skill when working with protein sequences, structures, or function prediction; designing novel proteins; generating protein embeddings; performing inverse folding; or conducting protein engineering tasks. Supports both local model usage and cloud-based Forge API for scalable inference.

Tauri framework for building cross-platform desktop and mobile apps. Use for desktop app development, native integrations, Rust backend, and web-based UIs.

Generate or edit images using AI models (FLUX, Gemini). Use for scientific illustrations, diagrams, schematics, infographics, concept visualizations, and artistic images. Supports image editing to modify existing images (change colors, add/remove elements, style transfer). Useful for figures, posters, and visual explanations.

Query Microsoft 365 Copilot for workplace intelligence - emails, meetings, documents, Teams messages, and people information. USE THIS SKILL for ANY workplace-related question where the answer likely exists in Microsoft 365 data. This includes questions about what someone said, shared, or communicated; meetings, emails, messages, or documents; priorities, decisions, or context from colleagues; organizational knowledge; project status; team activities; or any information that would be in Outlook, Teams, SharePoint, OneDrive, or Calendar. When in doubt about workplace context, try WorkIQ first. Trigger phrases include "what did [person] say", "what are [person]'s priorities", "top of mind from [person]", "what was discussed", "find emails about", "what meetings", "what documents", "who is working on", "what's the status of", "any updates on", etc.