Automated cell type annotation using reference-based methods including CellTypist, scPred, SingleR, and Azimuth for consistent, reproducible cell labeling. Use when automatically annotating cell types using reference datasets.

De novo motif discovery and known motif enrichment analysis using HOMER and MEME-ChIP. Identify transcription factor binding motifs in ChIP-seq, ATAC-seq, or other genomic peak data. Use when finding enriched DNA motifs in peak sequences.

Expert QA engineer specializing in comprehensive quality assurance, test strategy, and quality metrics. Masters manual and automated testing, test planning, and quality processes with focus on delivering high-quality software through systematic testing.

Real-time observability dashboard for multi-agent Claude Code sessions. Visualize agent interactions, tool usage, and session flows in real-time through a web dashboard. Track multiple agents running in parallel with swim lane visualization, event filtering, and live charts. USE WHEN user says 'start observability', 'agent dashboard', 'monitor agents', 'watch agent activity', 'multi-agent monitoring', 'track subagents', or needs to debug multi-agent workflows. **Key Features:** - 🔴 Real-time event streaming via WebSocket - 📊 Agent swim lanes showing parallel execution - 🔍 Event filtering by agent, session, event type - 📈 Live charts for tool usage patterns - 💾 Filesystem-based (no database required) **Inspired by [@indydevdan](https://github.com/indydevdan)**'s work on multi-agent observability. **Our approach:** Filesystem + in-memory streaming vs. indydevdan's SQLite database approach.

Compare OpenAI Codex GPT-5.2 and code-searcher responses for comprehensive dual-AI code analysis. Use when you need multiple AI perspectives on code questions.

This skill should be used when the user asks about "job status", "check if request completed", "cancel request", "why is my request taking so long", "poll for result", "batch requests", "retry failed request", "request timeout", "async operations", "job lifecycle", "manual polling", or needs advanced control over SDK async operations, manual job polling, batch processing, retry logic, or job cancellation.

Audit Solana programs (Anchor or native Rust) for security vulnerabilities. Use when reviewing smart contract security, finding exploits, analyzing attack vectors, performing security assessments, or when explicitly asked to audit, review security, check for bugs, or find vulnerabilities in Solana programs.

Create your Google Agent Development Kit skill in one prompt, then learn to improve it throughout the chapter

Create your Pipecat skill from official documentation, then learn to improve it throughout the chapter

Amazon Bedrock AgentCore Policy for defining agent boundaries using natural language and Cedar. Deterministic policy enforcement at the Gateway level. Use when setting agent guardrails, access control, tool permissions, or compliance rules.

Configure Tailwind CSS and shadcn/ui for React frontends with Django backends, including dark mode support and theme tokens. This skill should be used when setting up a new React project or adding Tailwind to an existing one.

Writing pull request titles and descriptions for the tldraw repository. Use when creating a new PR, updating an existing PR's title or body, or when the /pr command needs PR content guidance.

Expert LLM architect specializing in large language model architecture, deployment, and optimization. Masters LLM system design, fine-tuning strategies, and production serving with focus on building scalable, efficient, and safe LLM applications.

Expert research analyst specializing in comprehensive information gathering, synthesis, and insight generation. Masters research methodologies, data analysis, and report creation with focus on delivering actionable intelligence that drives informed decision-making.

Expert risk manager specializing in comprehensive risk assessment, mitigation strategies, and compliance frameworks. Masters risk modeling, stress testing, and regulatory compliance with focus on protecting organizations from financial, operational, and strategic risks.

Expert Scrum Master specializing in agile transformation, team facilitation, and continuous improvement. Masters Scrum framework implementation, impediment removal, and fostering high-performing, self-organizing teams that deliver value consistently.

Conduct structured interviews with the user. Use when multiple decisions need user input: ask ONE question at a time, wait for response, record answer, then proceed to next question.

Docker image reviews, optimization, and step-building guidance. Analyzes Dockerfiles for best practices, security issues, and anti-patterns.

Automated machine learning with hyperparameter optimization using Optuna, Hyperopt, or AutoML libraries. Activates for "automl", "hyperparameter tuning", "optimize hyperparameters", "auto tune model", "neural architecture search", "automated ml". Systematically explores model and hyperparameter spaces, tracks all experiments, and finds optimal configurations with minimal manual intervention.

Use the ClawdHub CLI to search, install, update, and publish agent skills from clawdhub.com. Use when you need to fetch new skills on the fly, sync installed skills to latest or a specific version, or publish new/updated skill folders with the npm-installed clawdhub CLI.