Expert in React Native native modules, bridging JavaScript and native code, writing custom native modules, using Turbo Modules, Fabric, JSI, autolinking, module configuration, iOS Swift/Objective-C modules, Android Kotlin/Java modules. Activates for native module, native code, bridge, turbo module, JSI, fabric, autolinking, custom native module, ios module, android module, swift, kotlin, objective-c, java native code.

This skill should be used when working with single-cell omics data analysis using scvi-tools, including scRNA-seq, scATAC-seq, CITE-seq, spatial transcriptomics, and other single-cell modalities. Use this skill for probabilistic modeling, batch correction, dimensionality reduction, differential expression, cell type annotation, multimodal integration, and spatial analysis tasks.

Primary Python tool for 40+ bioinformatics services. Preferred for multi-database workflows: UniProt, KEGG, ChEMBL, PubChem, Reactome, QuickGO. Unified API for queries, ID mapping, pathway analysis. For direct REST control, use individual database skills (uniprot-database, kegg-database).

CLI/Python toolkit for rapid bioinformatics queries. Preferred for quick BLAST searches. Access to 20+ databases: gene info (Ensembl/UniProt), AlphaFold, ARCHS4, Enrichr, OpenTargets, COSMIC, genome downloads. For advanced BLAST/batch processing, use biopython. For multi-database integration, use bioservices.

Execute Gemini CLI for AI-powered code analysis and generation. Use when you need to leverage Google's Gemini models for complex reasoning tasks.

Use when reviewing pull requests with comprehensive code analysis, incremental or full review options, and constructive feedback - provides thorough code reviews with severity ratings

Personalize COG for your workflow - creates profile, interests, and watchlist files with guided setup (run this first!)

Interactive scientific and statistical data visualization library for Python. Use when creating charts, plots, or visualizations including scatter plots, line charts, bar charts, heatmaps, 3D plots, geographic maps, statistical distributions, financial charts, and dashboards. Supports both quick visualizations (Plotly Express) and fine-grained customization (graph objects). Outputs interactive HTML or static images (PNG, PDF, SVG).

Autonomous biomedical AI agent framework for executing complex research tasks across genomics, drug discovery, molecular biology, and clinical analysis. Use this skill when conducting multi-step biomedical research including CRISPR screening design, single-cell RNA-seq analysis, ADMET prediction, GWAS interpretation, rare disease diagnosis, or lab protocol optimization. Leverages LLM reasoning with code execution and integrated biomedical databases.

Comprehensive Python library for astronomy and astrophysics. This skill should be used when working with astronomical data including celestial coordinates, physical units, FITS files, cosmological calculations, time systems, tables, world coordinate systems (WCS), and astronomical data analysis. Use when tasks involve coordinate transformations, unit conversions, FITS file manipulation, cosmological distance calculations, time scale conversions, or astronomical data processing.

Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis.

Primary Python toolkit for molecular biology. Preferred for Python-based PubMed/NCBI queries (Bio.Entrez), sequence manipulation, file parsing (FASTA, GenBank, FASTQ, PDB), advanced BLAST workflows, structures, phylogenetics. For quick BLAST, use gget. For direct REST API, use pubmed-database.

Comprehensive healthcare AI toolkit for developing, testing, and deploying machine learning models with clinical data. This skill should be used when working with electronic health records (EHR), clinical prediction tasks (mortality, readmission, drug recommendation), medical coding systems (ICD, NDC, ATC), physiological signals (EEG, ECG), healthcare datasets (MIMIC-III/IV, eICU, OMOP), or implementing deep learning models for healthcare applications (RETAIN, SafeDrug, Transformer, GNN).

Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.

Build Shopify applications, extensions, and themes using GraphQL/REST APIs, Shopify CLI, Polaris UI components, and Liquid templating. Capabilities include app development with OAuth authentication, checkout UI extensions for customizing checkout flow, admin UI extensions for dashboard integration, POS extensions for retail, theme development with Liquid, webhook management, billing API integration, product/order/customer management. Use when building Shopify apps, implementing checkout customizations, creating admin interfaces, developing themes, integrating payment processing, managing store data via APIs, or extending Shopify functionality.

Pythonic wrapper around RDKit with simplified interface and sensible defaults. Preferred for standard drug discovery: SMILES parsing, standardization, descriptors, fingerprints, clustering, 3D conformers, parallel processing. Returns native rdkit.Chem.Mol objects. For advanced control or custom parameters, use rdkit directly.

This skill provides symbol-level code understanding and navigation using Language Server Protocol (LSP). Enables IDE-like capabilities for finding symbols, tracking references, and making precise code edits at the symbol level.

Framework for computational fluid dynamics simulations using Python. Use when running fluid dynamics simulations including Navier-Stokes equations (2D/3D), shallow water equations, stratified flows, or when analyzing turbulence, vortex dynamics, or geophysical flows. Provides pseudospectral methods with FFT, HPC support, and comprehensive output analysis.

Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.

Query Microsoft 365 Copilot for workplace intelligence - emails, meetings, documents, Teams messages, and people information. USE THIS SKILL for ANY workplace-related question where the answer likely exists in Microsoft 365 data. This includes questions about what someone said, shared, or communicated; meetings, emails, messages, or documents; priorities, decisions, or context from colleagues; organizational knowledge; project status; team activities; or any information that would be in Outlook, Teams, SharePoint, OneDrive, or Calendar. When in doubt about workplace context, try WorkIQ first. Trigger phrases include "what did [person] say", "what are [person]'s priorities", "top of mind from [person]", "what was discussed", "find emails about", "what meetings", "what documents", "who is working on", "what's the status of", "any updates on", etc.